C-fos mRNA Induction in the Central and Peripheral Nervous Systems of Diisopropyl Phosphorofluoridate (DFP)-Treated Hens

A single dose of diisopropyl phosphorofluoridate (DFP), an organophosphorus ester, produces delayed neurotoxicity (OPIDN) in hen. DFP produces mild ataxia in hens in 7–14 days, which develops into severe ataxia or paralysis as the disease progresses. Since, OPIDN is associated with alteration in the expression of several proteins (e.g., Ca2+/calmodulin-dependent protein kinase II (CaM kinase…

MECHANISMS OF ORGANOPHOSPHORUS ESTER-INDUCED DELAYED NEUROTOXICITY: Type I and Type II

INTRODUCTION This review describes a group of organophosphorus compounds with delayed neurotoxic properties (I). Delayed neurotoxicity is a delayed onset of pro­longed locomotor ataxia resulting from a single or repeated exposure to an organophosphorus compound (2, 3). For many years, this effect was wrongly termed “demyelinization” or “demyelinating disease” because of the early misinterpretation of…

Air Travel and Health: an Update – House of Lords Science and Technology Committee

Public and media interest in contaminated air events, or fume events, has significantly increased in recent years. The independent Committee on Toxicity of Chemicals in Food Consumer Products and the Environment (COT) has conducted a scientific review of the evidence for claims that fume events have damaged the health of pilots and others, and has…