Impairment Of Glutamate Signaling In Mouse Central Nervous System Neurons In Vitro By Tri-O-Cresyl Phosphate (TOCP) At Non-Cytotoxic Concentrations

Occupational and environmental exposure to tri-cresyl phosphates (TCPs) may cause various types of neurotoxicity. Among the TCP isomers, tri-ortho-cresyl phosphate is a well-studied organophosphate (OP) known to cause OP-induced delayed neuropathy (OPIDN). Clinically, OPIDN is characterized by limb paralysis caused by the inhibition of neuropathy target esterase. Like other organophosphates, TOCP may also trigger acute…

Organophosphate Poisoning – Patient.co.uk

The organophosphate (OP) pesticides inhibit acetylcholinesterase. Hence acetylcholine accumulates at nerve synapses and neuromuscular junctions, stimulating muscarinic and nicotinic receptors and the central nervous system.They are used as pesticides but can also be used as ‘nerve gas’. This is prohibited under the Geneva Convention but could be used by terrorists or rogue regimes. Read the…

FUME EVENT: Same aircraft; two fume events in two days

A Lufthansa Airbus A321-200, registration D-AIRE performing flight LH-1132 from Frankfurt/Main (Germany) to Barcelona,SP (Spain), was descending towards Barcelona when a smell of old socks was detected in cabin and cockpit prompting the crew to don their oxygen masks. Read the full incident report A Lufthansa Airbus A321-200, registration D-AIRE […] was decending towards Frankfurt…

Autoantibody markers of neural degeneration are associated with post-mortem histopathological alterations of a neurologically-injured pilot

ABSTRACT. There are numerous concerns regarding the neurotoxicity of contaminated air inside pressurized aircraft. Neurological symptoms have been seen in many aircrew personnel who have reportedly been exposed to the potentially toxic breathable air in airliners. Symptoms, allegedly contracted by aircrew and passengers, are thought to be caused by a single large exposure or repetitive…