Health risk assessment of exposure to TriCresyl Phosphates (TCPs) in aircraft: A commentary

Abstract Possible exposure to TriCresyl Phosphates (TCPs) has led to concerns among airline crew members. One isomer, Tri-ortho-Cresyl Phosphate (ToCP) is known to be neurotoxic and exposure to ToCP via contaminated cabin air has been suggested to be associated with the alleged Aerotoxic syndrome. The symptoms associated with Aerotoxic syndrome are diverse, including headaches, loss…

Impairment Of Glutamate Signaling In Mouse Central Nervous System Neurons In Vitro By Tri-O-Cresyl Phosphate (TOCP) At Non-Cytotoxic Concentrations

Occupational and environmental exposure to tri-cresyl phosphates (TCPs) may cause various types of neurotoxicity. Among the TCP isomers, tri-ortho-cresyl phosphate is a well-studied organophosphate (OP) known to cause OP-induced delayed neuropathy (OPIDN). Clinically, OPIDN is characterized by limb paralysis caused by the inhibition of neuropathy target esterase. Like other organophosphates, TOCP may also trigger acute…

Organophosphate Poisoning – Patient.co.uk

The organophosphate (OP) pesticides inhibit acetylcholinesterase. Hence acetylcholine accumulates at nerve synapses and neuromuscular junctions, stimulating muscarinic and nicotinic receptors and the central nervous system.They are used as pesticides but can also be used as ‘nerve gas’. This is prohibited under the Geneva Convention but could be used by terrorists or rogue regimes. Read the…

Autoantibody markers of neural degeneration are associated with post-mortem histopathological alterations of a neurologically-injured pilot

ABSTRACT. There are numerous concerns regarding the neurotoxicity of contaminated air inside pressurized aircraft. Neurological symptoms have been seen in many aircrew personnel who have reportedly been exposed to the potentially toxic breathable air in airliners. Symptoms, allegedly contracted by aircrew and passengers, are thought to be caused by a single large exposure or repetitive…

Tricresyl phosphate and the aerotoxic syndrome of flight crew members – Current gaps in knowledge

Abstract Tricresyl phosphate (TCP), and in particular its tri-ortho substituted isomer (o,o,o-TCP), has been frequently used in aircraft engine oil. Bleed air, provided to the flight deck and cabin can contain traces of TCP. TCP can cause neurotoxic effects in humans. Regularly, airline pilots complain about loss of memory, headaches, dizziness, tunnel vision and other…